Quantitative Imaging Group
Department of Neurology
The Ohio State University
Department of Neurology
The Ohio State University
§ 01 About
The Quantitative Imaging Group, embedded in the Department of Neurology at The Ohio State University, develops microscopy and open-source image-analysis methods for quantitative studies of complex tissue microenvironments. Our work spans scales from dendritic spines to large-volume reconstruction, with active programs in brain, spinal cord, skin biopsy, and dorsal root ganglion imaging, in collaboration with groups at The Ohio State University and internationally.
Director
Luke Hammond
Department
Neurology, College of Medicine
§ 03 News
Latest updates.
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Preprint
May 2026
Clustered inputs maximize efficiency for stable place field encoding in CA1 pyramidal neurons.
A new bioRxiv preprint from the Poirazi Lab (FORTH-IMBB) and the Polleux Lab (Columbia), with contributions from the Quantitative Imaging Group, maps every excitatory and inhibitory synapse across the dendritic arbor of mouse CA1 pyramidal neurons in vivo and uses biophysical models to show how clustered excitatory inputs support efficient, stable place field encoding.
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Award
Apr 2026
Martin Patel awarded OSU STEP Mentoring Program funding.
Martin received an award from The Ohio State University's Second-year Transformational Experience Program, supporting his work on tissue processing in mouse and human skin.
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Preprint
Apr 2026
Mapping action-specific circuits in the external globus pallidus.
A new bioRxiv preprint led by researchers at UT Dallas, with collaborators at the Allen Institute for Neural Dynamics, Columbia University, and the Quantitative Imaging Group, reveals that the external globus pallidus (GPe) contains molecularly and anatomically distinct subpopulations forming parallel output channels linked to different behaviors. Luke Hammond contributed BrainJ-based whole-brain mapping and quantitative analysis.
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Publication
Mar 2026
Alternatively activated neutrophils limit T cell-driven neuroinflammation.
Published in Journal of Neuroinflammation. The Segal lab extends the alternatively activated neutrophil framework, established in their 2024 axon-regeneration study, to T cell-driven neuroinflammation in models relevant to multiple sclerosis. The Quantitative Imaging Group contributed histology guidance, imaging methods, and analysis to the study.
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