Collaborators

Multimodal study of the cellular mechanisms underlying chemotherapy-induced peripheral neuropathy and other sensory neuron disorders, with a focus on neuron-immune-skin interactions.

Interactions between the immune system and central nervous system in MS and other inflammatory conditions, with a focus on biomarkers that predict disease progression and treatment response, and mechanisms that promote repair and regeneration.

Immunotherapies that modulate the immune response after traumatic CNS injury, with a focus on neuroprotective and regenerative myeloid cells in axon regeneration.

Fundamental cellular mechanisms of inflammatory and injury responses in the nervous system, including how glial stress responses contribute to neuroinflammation in stroke, multiple sclerosis, and neurodegeneration.

Brain lipid composition, distribution, and signaling in aging and Alzheimer's disease, and the mechanisms through which these changes affect cellular function.

Experimental cancer pharmacology, focused on how targeted and cytotoxic chemotherapy impact the brain and the role of drug transporters in these effects.

Protein chemistry and biochemistry of cell signaling enzymes, focusing on how protein kinases and phosphatases function within cells, using chemoenzymatic protein semisynthesis.

Molecular mechanisms patterning cortical circuit connectivity during mammalian development, the genetic basis of human brain evolution, and synaptic loss in early Alzheimer's disease.

Peripheral nerve injury, neuropathic pain, and the cellular biology of dorsal root ganglion neurons; mechanisms of skin reinnervation after nerve injury.

Systems-level investigation of brain circuit dysfunction, combining behavioral analysis, imaging, electrophysiology, and optogenetics to study movement disorders such as dystonia and Parkinson's disease.

Brain mechanisms underlying movement and learning, using genetic, electrophysiological, optical, and behavioral approaches to investigate the neurobiology of action in health and disease.