Luke Hammond is a Co-Investigator on a new National Cancer Institute R01/R37 led by Eric D. Eisenmann examining how damage-associated molecular patterns (DAMPs) contribute to chemotherapy-induced toxicity.
The project also includes Grace Shin and the Shin Lab, long-term collaborators in applying quantitative imaging approaches to neuroimmune mechanisms and chemotherapy-induced peripheral neuropathy.
The seven-year award, R01/R37 CA299879, supports work at The Ohio State University to define mechanisms of chemotherapy-associated tissue injury and identify pathways that could be modulated to reduce off-target damage in patients receiving cancer therapy.
The Quantitative Imaging Group will develop and apply imaging and analysis workflows to measure tissue injury, cellular interactions, and spatial inflammatory responses, generating reproducible readouts for understanding DAMP-associated toxicity.